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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P42655




USC-OGP 2-DE database:  P42655


P42655


General information about the entry
View entry in simple text format
Entry name1433E_HUMAN
Primary accession numberP62258
Secondary accession number(s) P42655
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=14-3-3 protein epsilon; Short=14-3-3E;.
Gene nameName=YWHAE
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.62; Mw=30348

Cross-references
UniProtKB/Swiss-ProtP62258; 1433E_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry name1433E_HUMAN
Primary accession numberP62258
Secondary accession number(s) B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4
Sequence was last modified on July 5, 2004 (version 1)
Annotations were last modified on March 15, 2017 (version 153)
Name and origin of the protein
DescriptionRecName: Full=14-3-3 protein epsilon; Short=14-3-3E;
Gene nameName=YWHAE
Encoded onName=YWHAE
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLU20972; AAC50175.1; -; mRNA
EMBLU54778; AAC50710.1; -; mRNA
EMBLU43399; AAC50625.1; -; mRNA
EMBLU43430; AAD00026.1; -; mRNA
EMBLU28936; AAA75301.1; -; mRNA
EMBLAB017103; BAA32538.1; -; Genomic_DNA
EMBLAY883089; AAX68683.1; -; mRNA
EMBLAK128785; BAG54733.1; -; mRNA
EMBLAK295260; BAG58249.1; -; mRNA
EMBLAK316185; BAH14556.1; -; mRNA
EMBLBT007161; AAP35825.1; -; mRNA
EMBLCH471108; EAW90628.1; -; Genomic_DNA
EMBLCH471108; EAW90629.1; -; Genomic_DNA
EMBLBC000179; AAH00179.1; -; mRNA
EMBLBC001440; AAH01440.1; -; mRNA
CCDSCCDS11001.1; -. [P62258-1]; .
PIRA61235; A61235; .
PIRI38947; I38947; .
RefSeqNP_006752.1; NM_006761.4. [P62258-1]; .
UniGeneHs.513851; -; .
PDB2BR9; X-ray; 1.75 A; A=1-233
PDB3UAL; X-ray; 1.80 A; A=1-232
PDB3UBW; X-ray; 1.90 A; A=1-234
PDBsum2BR9; -; .
PDBsum3UAL; -; .
PDBsum3UBW; -; .
ProteinModelPortalP62258; -; .
SMRP62258; -; .
BioGrid113363; 390; .
DIPDIP-36676N; -; .
IntActP62258; 174; .
MINTMINT-4998623; -; .
STRING9606.ENSP00000264335; -; .
ChEMBLCHEMBL3329082; -; .
DrugBankDB01780; Fusicoccin; .
iPTMnetP62258; -; .
PhosphoSitePlusP62258; -; .
SwissPalmP62258; -; .
BioMutaYWHAE; -; .
DMDM51702210; -; .
OGPP42655; -; .
UCD-2DPAGEP62258; -; .
EPDP62258; -; .
PaxDbP62258; -; .
PeptideAtlasP62258; -; .
PRIDEP62258; -; .
TopDownProteomicsP62258-1; -. [P62258-1]; .
DNASU7531; -; .
EnsemblENST00000264335; ENSP00000264335; ENSG00000108953. [P62258-1]; .
EnsemblENST00000571732; ENSP00000461762; ENSG00000108953. [P62258-2]; .
EnsemblENST00000616643; ENSP00000481059; ENSG00000274474. [P62258-2]; .
EnsemblENST00000627231; ENSP00000487356; ENSG00000274474. [P62258-1]; .
GeneID7531; -; .
KEGGhsa:7531; -; .
UCSCuc002fsk.4; human. [P62258-1]; .
CTD7531; -; .
DisGeNET7531; -; .
GeneCardsYWHAE; -; .
H-InvDBHIX0013751; -; .
H-InvDBHIX0030006; -; .
HGNCHGNC:12851; YWHAE; .
HPACAB016200; -; .
HPACAB021109; -; .
HPACAB047350; -; .
HPAHPA008445; -; .
MalaCardsYWHAE; -; .
MIM605066; gene; .
neXtProtNX_P62258; -; .
OpenTargetsENSG00000108953; -; .
Orphanet217385; 17p13.3 microduplication syndrome; .
Orphanet261257; Distal 17p13.3 microdeletion syndrome; .
Orphanet531; Miller-Dieker syndrome; .
PharmGKBPA37440; -; .
eggNOGKOG0841; Eukaryota; .
eggNOGCOG5040; LUCA; .
GeneTreeENSGT00760000119116; -; .
HOVERGENHBG050423; -; .
InParanoidP62258; -; .
KOK06630; -; .
OMAKESALIM; -; .
OrthoDBEOG091G0VKY; -; .
PhylomeDBP62258; -; .
TreeFamTF102003; -; .
ReactomeR-HSA-111447; Activation of BAD and translocation to mitochondria; .
ReactomeR-HSA-1445148; Translocation of GLUT4 to the plasma membrane; .
ReactomeR-HSA-2028269; Signaling by Hippo; .
ReactomeR-HSA-205025; NADE modulates death signalling; .
ReactomeR-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; .
ReactomeR-HSA-3371453; Regulation of HSF1-mediated heat shock response; .
ReactomeR-HSA-3371511; HSF1 activation; .
ReactomeR-HSA-380259; Loss of Nlp from mitotic centrosomes; .
ReactomeR-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; .
ReactomeR-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; .
ReactomeR-HSA-5620912; Anchoring of the basal body to the plasma membrane; .
ReactomeR-HSA-5625740; RHO GTPases activate PKNs; .
ReactomeR-HSA-5628897; TP53 Regulates Metabolic Genes; .
ReactomeR-HSA-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; .
ReactomeR-HSA-8854518; AURKA Activation by TPX2; .
ReactomeR-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; .
ReactomeR-HSA-8876198; RAB GEFs exchange GTP for GDP on RABs; .
SignaLinkP62258; -; .
SIGNORP62258; -; .
ChiTaRSYWHAE; human; .
EvolutionaryTraceP62258; -; .
GeneWikiYWHAE; -; .
GenomeRNAi7531; -; .
PMAP-CutDBP62258; -; .
PROPR:P62258; -; .
ProteomesUP000005640; Chromosome 17; .
BgeeENSG00000108953; -; .
CleanExHS_YWHAE; -; .
ExpressionAtlasP62258; baseline and differential; .
GenevisibleP62258; HS; .
GOGO:0030424; C:axon; IEA:Ensembl; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0005871; C:kinesin complex; IEA:Ensembl; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0005739; C:mitochondrion; IEA:Ensembl; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0045296; F:cadherin binding; IDA:BHF-UCL; .
GOGO:0019899; F:enzyme binding; IPI:UniProtKB; .
GOGO:0042826; F:histone deacetylase binding; IPI:BHF-UCL; .
GOGO:0044325; F:ion channel binding; IPI:BHF-UCL; .
GOGO:0023026; F:MHC class II protein complex binding; IDA:UniProtKB; .
GOGO:0051219; F:phosphoprotein binding; IPI:BHF-UCL; .
GOGO:0050815; F:phosphoserine binding; IPI:BHF-UCL; .
GOGO:0015459; F:potassium channel regulator activity; IDA:BHF-UCL; .
GOGO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL; .
GOGO:0017112; F:Rab guanyl-nucleotide exchange factor activity; TAS:Reactome; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; .
GOGO:0034605; P:cellular response to heat; IDA:UniProtKB; .
GOGO:0021987; P:cerebral cortex development; IEA:Ensembl; .
GOGO:0097711; P:ciliary basal body docking; TAS:Reactome; .
GOGO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0035329; P:hippo signaling; TAS:Reactome; .
GOGO:0021766; P:hippocampus development; IEA:Ensembl; .
GOGO:0035556; P:intracellular signal transduction; TAS:ProtInc; .
GOGO:0000165; P:MAPK cascade; IDA:UniProtKB; .
GOGO:0061024; P:membrane organization; TAS:Reactome; .
GOGO:0086013; P:membrane repolarization during cardiac muscle cell action potential; IC:BHF-UCL; .
GOGO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome; .
GOGO:1902309; P:negative regulation of peptidyl-serine dephosphorylation; IDA:BHF-UCL; .
GOGO:0001764; P:neuron migration; IEA:Ensembl; .
GOGO:0046827; P:positive regulation of protein export from nucleus; IDA:UniProtKB; .
GOGO:1900740; P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; TAS:Reactome; .
GOGO:0006605; P:protein targeting; IEA:Ensembl; .
GOGO:1900034; P:regulation of cellular response to heat; TAS:Reactome; .
GOGO:0086091; P:regulation of heart rate by cardiac conduction; IC:BHF-UCL; .
GOGO:0003064; P:regulation of heart rate by hormone; NAS:BHF-UCL; .
GOGO:0060306; P:regulation of membrane repolarization; IDA:BHF-UCL; .
GOGO:1901016; P:regulation of potassium ion transmembrane transporter activity; IDA:BHF-UCL; .
GOGO:0021762; P:substantia nigra development; IEP:UniProtKB; .
GOGO:0016032; P:viral process; IEA:UniProtKB-KW; .
Gene3D1.20.190.20; -; 1; .
InterProIPR000308; 14-3-3; .
InterProIPR023409; 14-3-3_CS; .
InterProIPR023410; 14-3-3_domain; .
PANTHERPTHR18860; PTHR18860; 1; .
PfamPF00244; 14-3-3; 1; .
PIRSFPIRSF000868; 14-3-3; 1; .
PRINTSPR00305; 1433ZETA; .
SMARTSM00101; 14_3_3; 1; .
SUPFAMSSF48445; SSF48445; 1; .
PROSITEPS00796; 1433_1; 1; .
PROSITEPS00797; 1433_2; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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